Cycloaddition of cyclobutenone and azomethine imine enabled by chiral isothiourea organic catalysts

• Main Authors: Li, Bao-Sheng, Wang, Yuhuang, Jin, Zhichao, Chi, Robin Yonggui
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Chemistry::Physical chemistry::Catalysis
• Online Access: https://hdl.handle.net/10356/96149; http://hdl.handle.net/10220/38479
• Institution: Nanyang Technological University

The addition of an organic catalyst to the ketone moiety of a γ-mono-chloride substituted cyclobutenone destroys its stable, conjugated and nearly planar structure. The C–C bond in the resulting less stable anionic oxy-substituted non-planar intermediate is then activated. The breaking of one C–C si...