Structure of Arabidopsis CESA3 catalytic domain with its substrate UDP-glucose provides insight into the mechanism of cellulose synthesis

• Main Authors: Qiao, Zhu, Lampugnani, Edwin R., Yan, Xin-Fu, Khan, Ghazanfar Abbas, Saw, Wuan Geok, Hannah, Patrick, Qian, Feng, Calabria, Jacob, Miao, Yansong, Grüber, Gerhard, Persson, Staffan, Gao, Yong-Gui
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Biological sciences; Cellulose Synthase; Structural Biology
• Online Access: https://hdl.handle.net/10356/148273
• Institution: Nanyang Technological University

Cellulose is synthesized by cellulose synthases (CESAs) from the glycosyltransferase GT-2 family. In plants, the CESAs form a six-lobed rosette-shaped CESA complex (CSC). Here we report crystal structures of the catalytic domain of Arabidopsis thaliana CESA3 (AtCESA3CatD) in both apo and uridine dip...