Peptide asparaginyl ligases—renegade peptide bond makers

• Main Authors: Tam, James P., Chan, Ning-Yu, Liew, Heng Tai, Tan, Shaun J., Chen, Yu
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science; Asparaginyl Endopeptidase; Asn-specific Ligation
• Online Access: https://hdl.handle.net/10356/148282
• Institution: Nanyang Technological University

Making peptide bonds is tightly controlled by genetic code and machinery which includes cofactors, ATP, and RNAs. In this regard, the stand-alone and genetic-code-independent peptide ligases constitute a new family of renegade peptide-bond makers. A prime example is butelase-1, an Asn/Asp(Asx)-speci...