Development of ratiometric fluorescent pH nanoprobe to study endocytic uptake pathways of antisense oligonucleotides

• 主要作者: Liew, Donn Hou Feng
• 其他作者: Phan Anh Tuan
• 格式: Final Year Project
• 語言: English
• 出版: Nanyang Technological University 2021
• 主題: Science::Biological sciences::Biophysics; Science::Physics::Optics and light
• 在線閱讀: https://hdl.handle.net/10356/148512
• 機構: Nanyang Technological University

Anti-sense oligonucleotides (ASOs) are single short strands of synthetic DNA/RNA designed to complement specific RNA sequences. Antisense therapy as a treatment option has received widespread consideration as only knowledge of a nucleotide sequence is necessary for drug design. However, one challeng...