Access to optically enriched α-aryloxycarboxylic esters via carbene-catalyzed dynamic kinetic resolution and transesterification

• Main Authors: Liu, Bin, Song, Runjiang, Xu, Jun, Majhi, Kumar Pankaj, Yang, Xing, Yang, Song, Jin, Zhichao, Chi, Robin Yonggui
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Chemistry; Chemical Reactions; Substituents
• Online Access: https://hdl.handle.net/10356/148640
• Institution: Nanyang Technological University

Optically active α-aryloxycarboxylic acids and their derivatives are important functional molecules. Disclosed here is a carbene-catalyzed dynamic kinetic resolution and transesterification reaction for access to this class of molecules with up to 99% yields and 99:1 er values. Addition of a chiral...