Dual inhibition of the terminal oxidases eradicates antibiotic-tolerant Mycobacterium tuberculosis

• Main Authors: Lee, Bei Shi, Hards, Kiel, Engelhart, Curtis A., Hasenoehrl, Erik J., Kalia, Nitin Pal, Mackenzie, Jared S., Sviriaeva, Ekaterina, Chong, Sherilyn Shi Min, Manimekalai, Malathy Sony S., Koh, Vanessa H., Chan, John, Xu, Jiayong, Alonso, Sylvie, Miller, Marvin J., Steyn, Adrie J. C., Grüber, Gerhard, Schnappinger, Dirk, Berney, Michael, Cook, Gregory M., Moraski, Garrett C., Pethe, Kevin
• 其他作者: School of Biological Sciences
• 格式: Article
• 語言: English
• 出版: 2021
• 主題: Science::Chemistry::Biochemistry; Antibiotic-tolerance; Cytochrome bcc-aa3
• 在線閱讀: https://hdl.handle.net/10356/149224

The approval of bedaquiline has placed energy metabolism in the limelight as an attractive target space for tuberculosis antibiotic development. While bedaquiline inhibits the mycobacterial F1F0 ATP synthase, small molecules targeting other components of the oxidative phosphorylation pathway have be...