Zika virus nonstructural protein 5 residue R681 is critical for dimer formation and enzymatic activity

Zika virus (ZIKV) relies on its nonstructural protein 5 (NS5) for capping and synthesis of the viral RNA. Recent small-angle X-ray scattering (SAXS) data of recombinant ZIKV NS5 protein showed that it is dimeric in solution. Here, we present insights into the critical residues responsible for its di...

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Bibliographic Details
Main Authors: Saw, Wuan-Geok, Chan, Kitti Wing-Ki, Vasudevan, Subhash G., Grüber, Gerhard
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2021
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Online Access:https://hdl.handle.net/10356/149251
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Institution: Nanyang Technological University
Language: English