Zika virus nonstructural protein 5 residue R681 is critical for dimer formation and enzymatic activity
Zika virus (ZIKV) relies on its nonstructural protein 5 (NS5) for capping and synthesis of the viral RNA. Recent small-angle X-ray scattering (SAXS) data of recombinant ZIKV NS5 protein showed that it is dimeric in solution. Here, we present insights into the critical residues responsible for its di...
Saved in:
Main Authors: | Saw, Wuan-Geok, Chan, Kitti Wing-Ki, Vasudevan, Subhash G., Grüber, Gerhard |
---|---|
Other Authors: | School of Biological Sciences |
Format: | Article |
Language: | English |
Published: |
2021
|
Subjects: | |
Online Access: | https://hdl.handle.net/10356/149251 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Nanyang Technological University |
Language: | English |
Similar Items
-
Cell-active carbazole derivatives as inhibitors of the zika virus protease
by: Rassias, Gerasimos, et al.
Published: (2021) -
Zika in travellers 1947-2017 : a systematic review
by: Wilder-Smith, Annelies, et al.
Published: (2020) -
Structure and flexibility of non-structural proteins 3 and -5 of Dengue- and Zika viruses in solution
by: Saw, Wuan Geok, et al.
Published: (2020) -
Zika Virus NS5 Forms Supramolecular Nuclear Bodies That Sequester Importin-a and Modulate the Host Immune and Pro-Inflammatory Response in Neuronal Cells
by: Ivan H. W. Ng, et al.
Published: (2020) -
Optimal flexibility of the linker region of Zika virus NS5 methyltransferase-polymerase is critical for virus replication
by: Charlotte Flory, et al.
Published: (2022)