Structural insights into the inhibition of Zika virus NS2B-NS3 protease by a small-molecule inhibitor

Structural insights into the inhibition of Zika virus NS2B-NS3 protease by a small-molecule inhibitor

Zika virus (ZIKV) infection has become a global public health concern. The viral NS2B-NS3 protease is an attractive antiviral target because of its role in maturation of viral non-structural proteins. Substrate-derived protease inhibitors have been investigated, but it remains challenging to develop...

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Bibliographic Details
Main Authors: Li, Yan, Zhang, Zhenzhen, Phoo, Wint Wint, Loh, Ying Ru, Li, Rong, Yang, Hai Yan, Jansson, Anna E., Hill, Jeffrey, Keller, Thomas H., Nacro, Kassoum, Luo, Dahai, Kang, CongBao
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2020
Subjects:
Science::Biological sciences
Zika Virus
Protease
Online Access:https://hdl.handle.net/10356/140349
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/140349

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