Identification and structural characterization of small molecule fragments targeting Zika virus NS2B-NS3 protease

• Main Authors: Quek, Jun Ping, Liu, Shuang, Zhang, Zhenzhen, Li, Yan, Ng, Elizabeth Yihui, Loh, Ying Ru, Hung, Alvin W., Luo, Dahai, Kang, CongBao
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Medicine; Zika Virus; Fragment-based Drug Discovery
• Online Access: https://hdl.handle.net/10356/140769
• Institution: Nanyang Technological University

Zika virus (ZIKV) NS2B-NS3 protease is a validated antiviral target as it is essential for maturation of viral proteins. However, its negatively charged active site hinders the development of orthosteric small-molecule inhibitors. Fragment-based drug discovery (FBDD) is a powerful tool to generate n...