Zika virus nonstructural protein 5 residue R681 is critical for dimer formation and enzymatic activity

by Saw, Wuan-Geok, Chan, Kitti Wing-Ki, Vasudevan, Subhash G., Grüber, Gerhard
Published 2021

Luteolin escape mutants of dengue virus map to prM and NS2B and reveal viral plasticity during maturation

by Vasudevan, Subhash G., Peng, Minhua, Swarbrick, Crystall Marie Dawn, Chan, Kitti Wing-Ki, Luo, Dahai, Zhang, Wei, Lai, Xiaoping, Li, Geng
Published 2019

A conserved arginine in NS5 binds genomic 3' stem-loop RNA for primer-independent initiation of flavivirus RNA replication

by Wang, Sai, Chan, Kitti Wing Ki, Tan, Min Jie Alvin, Flory, Charlotte, Luo, Dahai, Lescar, Julian, Forwood, Jade K., Vasudevan, Subhash G.
Published 2022

Luteolin restricts dengue virus replication through inhibition of the proprotein convertase furin

by Peng, Minhua, Watanabe, Satoru, Chan, Kitti Wing Ki, He, Qiuyan, Zhao, Ya, Zhang, Zhongde, Lai, Xiaoping, Luo, Dahai, Vasudevan, Subhash G., Li, Geng
Published 2017

Non-nucleoside inhibitors of Zika virus RNA-dependent RNA polymerase

by Gharbi-Ayachi, Aïcha, Santhanakrishnan, Sridhar, Wong, Yee Hwa, Chan, Kitti Wing Ki, Tan, Siok Thing, Bates, Roderick Wayland, Vasudevan, Subhash G., El Sahili, Abbas, Lescar, Julien
Published 2020

Flexibility of NS5 Methyltransferase-Polymerase Linker Region Is Essential for Dengue Virus Replication

by Zhao, Yongqian, Soh, Tingjin Sherryl, Chan, Kitti Wing Ki, Fung, Sarah Suet Yin, Swaminathan, Kunchithapadam, Lim, Siew Pheng, Shi, Pei-Yong, Huber, Thomas, Lescar, Julien, Luo, Dahai, Vasudevan, Subhash G.
Published 2015

18F-fluorodeoxyglucose positron emission tomography as a window into human dengue pathophysiology

by Kalimuddin, Shirin, Xie, Wanying, Watanabe, Satoru, Tham, Jing Yang, Sam, Huizhen, Chan, Kitti Wing Ki, Yap, Tiang Siew, Totman, John J., Chacko, Ann-Marie, Vasudevan, Subhash G., Low, Jenny G.
Published 2022

Cell-active carbazole derivatives as inhibitors of the zika virus protease

by Rassias, Gerasimos, Zogali, Vasiliki, Swarbrick, Crystall M. D., Chan, Kitti Wing Ki, Chan, Shu Ann, Gwee, Chin Piaw, Wang, Sai, Kaplanai, Entzy, Canko, Aleksander, Kiousis, Dimitrios, Lescar, Julien, Luo, Dahai, Matsoukas, Minos-Timotheos, Vasudevan, Subhash G.
Published 2021

A crystal structure of the dengue virus NS5 protein reveals a novel inter-domain interface essential for protein flexibility and virus replication

by Zhao, Yongqian, Soh, Tingjin Sherryl, Zheng, Jie, Chan, Kitti Wing Ki, Phoo, Wint Wint, Lee, Chin Chin, Tay, Moon Y. F., Swaminathan, Kunchithapadam, Cornvik, Tobias Carl, Lim, Siew Pheng, Shi, Pei-Yong, Lescar, Julien, Vasudevan, Subhash G., Luo, Dahai
Published 2015

A T164S mutation in the dengue virus NS1 protein is associated with greater disease severity in mice

by Chan, Kitti Wing Ki, Watanabe, Satoru, Jin, Jocelyn Y, Pompon, Julien, Teng, Don, Alonso, Sylvie, Vijaykrishna, Dhanasekaran, Halstead, Scott B, Marzinek, Jan K, Bond, Peter J, Burla, Bo, Torta, Federico, Wenk, Markus R, Ooi, Eng Eong, Vasudevan, Subhash G
Published 2020