The C-terminal 50 amino acid residues of dengue NS3 protein are important for NS3-NS5 interaction and viral replication

• Main Authors: Tay, Moon Y. F., Saw, Wuan Geok, Zhao, Yongqian, Chan, Kitti W. K., Singh, Daljit, Chong, Yuwen, Forwood, Jade K., Ooi, Eng Eong, Grüber, Gerhard, Lescar, Julien, Luo, Dahai, Vasudevan, Subhash G.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: Plus-stranded RNA virus; Flavivirus; DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/88989; http://hdl.handle.net/10220/46048
• Institution: Nanyang Technological University

Dengue virus multifunctional proteins NS3 protease/helicase and NS5 methyltransferase/RNA-dependent RNA polymerase form part of the viral replication complex and are involved in viral RNA genome synthesis, methylation of the 5′-cap of viral genome, and polyprotein processing among other activities....