Zika virus nonstructural protein 5 residue R681 is critical for dimer formation and enzymatic activity

• المؤلفون الرئيسيون: Saw, Wuan-Geok, Chan, Kitti Wing-Ki, Vasudevan, Subhash G., Grüber, Gerhard
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2021
• الموضوعات: Science::Biological sciences::Biochemistry; Flavivirus; Zika
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/149251
• المؤسسة: Nanyang Technological University

Zika virus (ZIKV) relies on its nonstructural protein 5 (NS5) for capping and synthesis of the viral RNA. Recent small-angle X-ray scattering (SAXS) data of recombinant ZIKV NS5 protein showed that it is dimeric in solution. Here, we present insights into the critical residues responsible for its di...