Regulation of cell migration by BMP signaling
A morphogen is a soluble signaling molecule which instructs cellular processes in a concentration-dependent manner. Bone morphogenetic proteins (BMP) are morphogens essential for development and repair in both embryos and adults. Preliminary observations in our group suggested that BMP signaling may...
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2021
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sg-ntu-dr.10356-1493802023-02-28T18:08:15Z Regulation of cell migration by BMP signaling Leong, Leslie Boon Hao Tom James Carney School of Biological Sciences Experimental Medicine Building, Lee Kong Chian School of Medicine tcarney@ntu.edu.sg Science::Biological sciences::Genetics A morphogen is a soluble signaling molecule which instructs cellular processes in a concentration-dependent manner. Bone morphogenetic proteins (BMP) are morphogens essential for development and repair in both embryos and adults. Preliminary observations in our group suggested that BMP signaling may play a role during fibroblast migration in the developing fin of zebrafish embryos. By introducing BMP inhibitors to chemically block BMP signaling, retardation of fibroblast migration in the fin was observed. However, the exact mechanism of BMP signaling in directing cell migration in the developing fin is still unclear. Therefore, the aim of this project is to further investigate the role of BMP signaling in directing cell migration in the fin. In addition to chemical inhibition, BMP signaling was disrupted genetically by establishing transgenic zebrafish that conditionally overexpresses dominant-negative form of BMPR1ba (DNBMPR1ba). This was followed by observing its effect on fibroblast migration in the fin. Our results indicate that disruption of BMP signaling genetically also result in retardation of fibroblast migration in the developing fin, thus implying the importance of BMP signaling in directing migration of mesodermal-derived fibroblasts in the fin. Bachelor of Science in Biological Sciences 2021-06-08T13:48:50Z 2021-06-08T13:48:50Z 2021 Final Year Project (FYP) Leong, L. B. H. (2021). Regulation of cell migration by BMP signaling. Final Year Project (FYP), Nanyang Technological University, Singapore. https://hdl.handle.net/10356/149380 https://hdl.handle.net/10356/149380 en SBS20-179 application/pdf Nanyang Technological University |
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Science::Biological sciences::Genetics Leong, Leslie Boon Hao Regulation of cell migration by BMP signaling |
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A morphogen is a soluble signaling molecule which instructs cellular processes in a concentration-dependent manner. Bone morphogenetic proteins (BMP) are morphogens essential for development and repair in both embryos and adults. Preliminary observations in our group suggested that BMP signaling may play a role during fibroblast migration in the developing fin of zebrafish embryos. By introducing BMP inhibitors to chemically block BMP signaling, retardation of fibroblast migration in the fin was observed. However, the exact mechanism of BMP signaling in directing cell migration in the developing fin is still unclear. Therefore, the aim of this project is to further investigate the role of BMP signaling in directing cell migration in the fin. In addition to chemical inhibition, BMP signaling was disrupted genetically by establishing transgenic zebrafish that conditionally overexpresses dominant-negative form of BMPR1ba (DNBMPR1ba). This was followed by observing its effect on fibroblast migration in the fin. Our results indicate that disruption of BMP signaling genetically also result in retardation of fibroblast migration in the developing fin, thus implying the importance of BMP signaling in directing migration of mesodermal-derived fibroblasts in the fin. |
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Tom James Carney |
author_facet |
Tom James Carney Leong, Leslie Boon Hao |
format |
Final Year Project |
author |
Leong, Leslie Boon Hao |
author_sort |
Leong, Leslie Boon Hao |
title |
Regulation of cell migration by BMP signaling |
title_short |
Regulation of cell migration by BMP signaling |
title_full |
Regulation of cell migration by BMP signaling |
title_fullStr |
Regulation of cell migration by BMP signaling |
title_full_unstemmed |
Regulation of cell migration by BMP signaling |
title_sort |
regulation of cell migration by bmp signaling |
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Nanyang Technological University |
publishDate |
2021 |
url |
https://hdl.handle.net/10356/149380 |
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1759857714749505536 |