Backbone resonance assignment for the N-terminal region of bacterial tRNA-(N1G37) methyltransferase

• Main Authors: Yan, Li, Zhong, Wenhe, Koay, Ann Zhufang, Ng, Hui Qi, Koh‑Stenta, Xiaoying, Nah, Qianhui, Lim, Siau Hoi, Larsson, Andreas, Lescar, Julien, Hill, Jeffrey, Dedon, Peter C., Kang, CongBao
• 其他作者: School of Biological Sciences
• 格式: Article
• 語言: English
• 出版: 2021
• 主題: Science::Biological sciences; tRNA Methyltransferase; Antibacterial
• 在線閱讀: https://hdl.handle.net/10356/150609
• 機構: Nanyang Technological University

Bacterial tRNA (guanine37-N1)-methyltransferase (TrmD) is an important antibacterial target due to its essential role in translation. TrmD has two domains connected with a flexible linker. The N-terminal domain (NTD) of TrmD contains the S-adenosyl-l-methionine (SAM) cofactor binding site and the C-...