A new method for the construction of coarse-grained models of large biomolecules from low-resolution cryo-electron microscopy data

• Main Authors: Zhang, Yuwei, Xia, Kelin, Cao, Zexing, Gräter, Frauke, Xia, Fei
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Chemistry; Amino-acid-sequence; Force-field
• Online Access: https://hdl.handle.net/10356/150624
• Institution: Nanyang Technological University

The rapid development of cryo-electron microscopy (cryo-EM) has led to the generation of significant low-resolution electron density data of biomolecules. However, the atomistic details of huge biomolecules usually cannot be obtained because it is very difficult to construct all-atom models for MD s...