Generation of a heteropolycyclic and sp3-rich scaffold for library synthesis from a highly diastereoselective Petasis/Diels–Alder and ROM–RCM reaction sequence
Efficient access to diverse screening compounds with desirable, lead-like properties can be a bottleneck in early drug discovery and chemical biology. Herein we present an efficient, rapid route to three structurally distinct classes of compounds (A–C) from a single precursor, which in turn is avail...
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Main Authors: | , , , , , , , , , , , |
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Other Authors: | |
Format: | Article |
Language: | English |
Published: |
2021
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Subjects: | |
Online Access: | https://hdl.handle.net/10356/150792 |
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Institution: | Nanyang Technological University |
Language: | English |