Petasis/Diels-Alder/cyclization cascade reactions for the generation of scaffolds with multiple stereogenic centers and orthogonal handles for library production
A new effective strategy for the synthesis of sp3-rich small molecules for library production is presented. The key steps to generate complexity involve a Petasis three-component reaction followed by an intramolecular Diels–Alder and cyclization to generate a densely enriched tricyclic or tetracycli...
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Main Authors: | , , , , , , |
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Other Authors: | |
Format: | Article |
Language: | English |
Published: |
2020
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Subjects: | |
Online Access: | https://hdl.handle.net/10356/140820 |
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Institution: | Nanyang Technological University |
Language: | English |