Petasis/Diels-Alder/cyclization cascade reactions for the generation of scaffolds with multiple stereogenic centers and orthogonal handles for library production

A new effective strategy for the synthesis of sp3-rich small molecules for library production is presented. The key steps to generate complexity involve a Petasis three-component reaction followed by an intramolecular Diels–Alder and cyclization to generate a densely enriched tricyclic or tetracycli...

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Bibliographic Details
Main Authors: Flagstad, Thomas, Azevedo, Carlos M. G., Min, Geanna, Willaume, Anthony, Morgentin, Rémy, Nielsen, Thomas E., Clausen, Mads Hartvig
Other Authors: Singapore Centre for Environmental Life Sciences and Engineering
Format: Article
Language:English
Published: 2020
Subjects:
Online Access:https://hdl.handle.net/10356/140820
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Institution: Nanyang Technological University
Language: English
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