Petasis/Diels-Alder/cyclization cascade reactions for the generation of scaffolds with multiple stereogenic centers and orthogonal handles for library production
A new effective strategy for the synthesis of sp3-rich small molecules for library production is presented. The key steps to generate complexity involve a Petasis three-component reaction followed by an intramolecular Diels–Alder and cyclization to generate a densely enriched tricyclic or tetracycli...
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| Main Authors: | , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
2020
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/140820 |
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| Institution: | Nanyang Technological University |
| Language: | English |