Generation of a heteropolycyclic and sp3-rich scaffold for library synthesis from a highly diastereoselective Petasis/Diels–Alder and ROM–RCM reaction sequence

• Main Authors: Flagstad, Thomas, Azevedo, Carlos M. G., Troelsen, Nikolaj S., Min, Geanna K., Macé, Yohan, Willaume, Anthony, Guilleux, Rachel, Velay, Mélanie, Bonnet, Karine, Morgentin, Remy, Nielsen, Thomas E., Clausen, Mads H.
• Other Authors: Singapore Centre for Environmental Life Sciences and Engineering
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Chemistry; Drug Discovery; Heterocycles
• Online Access: https://hdl.handle.net/10356/150792
• Institution: Nanyang Technological University

Efficient access to diverse screening compounds with desirable, lead-like properties can be a bottleneck in early drug discovery and chemical biology. Herein we present an efficient, rapid route to three structurally distinct classes of compounds (A–C) from a single precursor, which in turn is avail...