A C-terminal peptide of TFPI-1 facilitates cytosolic delivery of nucleic acid cargo into mammalian cells

• المؤلفون الرئيسيون: Fazil, Mobashar Hussain Urf Turabe, Chalasani, Madhavi Latha Somaraju, Choong, Yeu Khai, Schmidtchen, Artur, Verma, Navin Kumar, Saravanan, Rathi
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2021
• الموضوعات: Science::Medicine; Host Defence Peptide; Intracellular Gene Delivery
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/151502

Efficient intracellular nucleic acid delivery into mammalian cells remains a long-standing challenge owing to poor cell permeability and uptake of naked nucleic acids across the cell membrane and limited cargo stability. Conventional delivery methods have several drawbacks, such as cytotoxicity, lim...