Methionine is a metabolic dependency of tumor-initiating cells

• Main Authors: Wang, Zhenxun, Yip, Lian Yee, Lee, Jane Jia Hui, Wu, Zhengwei, Chew, Hui Yi, Chong, William Pooi Kiat, Teo, Chin Chye, Ang, Heather Yin-Kuan, Peh, Esther Kai Lay, Yuan, Ju, Ma, Siming, Choo, Kimberly Li Shi, Basri, Nurhidayah, Jiang, Xia, Yu, Qiang, Hillmer, Axel M., Lim, Wan Teck, Lim, Tony Kiat Hon, Takano, Angela, Tan, Eng Huat, Tan, Daniel Shao Weng, Ho, Ying Swan, Lim, Bing, Tam, Wai Leong
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Biological sciences; Amino Acid Requirements; Cancer Stem-cells
• Online Access: https://hdl.handle.net/10356/151732
• Institution: Nanyang Technological University

Understanding cellular metabolism holds immense potential for developing new classes of therapeutics that target metabolic pathways in cancer. Metabolic pathways are altered in bulk neoplastic cells in comparison to normal tissues. However, carcinoma cells within tumors are heterogeneous, and tumor-...