IRE-1 regulates cellular homeostasis during disrupted lipid metabolism

Metabolic disorders, such as non-alcoholic fatty liver disease (NAFLD), are emerging as epidemics that affect the global population. One facet of these disorders is attributed to the disturbance of membrane lipid composition. Typically activated by misfolded protein accumulation within the ER, pertu...

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Bibliographic Details
Main Author: Koh, Jhee Hong
Other Authors: Guillaume Thibault
Format: Thesis-Doctor of Philosophy
Language:English
Published: Nanyang Technological University 2021
Subjects:
Online Access:https://hdl.handle.net/10356/152743
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Institution: Nanyang Technological University
Language: English