Preparation and dynamic behavior of protein-polymer complexes formed with polymer-binding peptides

Preparation and dynamic behavior of protein-polymer complexes formed with polymer-binding peptides

The development of protein-polymer complexes using protein cages is garnering attention as a strategy to overcome challenges that relate to immunogenicity and protease degradation. We propose the use of thermoresponsive polymers such as poly(N-isopropylacrylamide) (PNIPAM) to form ferritin-polymer c...

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Main Authors: Ravishankar, Samyukta, Suzuki, Seigo, Sawada, Toshiki, Lim, Sierin, Serizawa, Takeshi
Other Authors: School of Chemical and Biomedical Engineering
Format: Article
Language:English
Published: 2021
Subjects:
Engineering::Chemical engineering
Ferritin
Protein-PNIPAM Complexes
Online Access:https://hdl.handle.net/10356/152844
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1528442021-10-08T06:00:30Z Preparation and dynamic behavior of protein-polymer complexes formed with polymer-binding peptides Ravishankar, Samyukta Suzuki, Seigo Sawada, Toshiki Lim, Sierin Serizawa, Takeshi School of Chemical and Biomedical Engineering Engineering::Chemical engineering Ferritin Protein-PNIPAM Complexes The development of protein-polymer complexes using protein cages is garnering attention as a strategy to overcome challenges that relate to immunogenicity and protease degradation. We propose the use of thermoresponsive polymers such as poly(N-isopropylacrylamide) (PNIPAM) to form ferritin-polymer complexes through non-covalent interactions. Ferritin is observed to be released from the complexes after 1–2 days incubation at 37 °C. 2021-10-08T06:00:30Z 2021-10-08T06:00:30Z 2020 Journal Article Ravishankar, S., Suzuki, S., Sawada, T., Lim, S. & Serizawa, T. (2020). Preparation and dynamic behavior of protein-polymer complexes formed with polymer-binding peptides. Bulletin of the Chemical Society of Japan, 93(6), 790-793. https://dx.doi.org/10.1246/bcsj.20200021 0009-2673 https://hdl.handle.net/10356/152844 10.1246/bcsj.20200021 6 93 790 793 en Bulletin of the Chemical Society of Japan © 2020 The Chemical Society of Japan. All rights reserved.
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Engineering::Chemical engineering
Ferritin
Protein-PNIPAM Complexes
spellingShingle Engineering::Chemical engineering
Ferritin
Protein-PNIPAM Complexes
Ravishankar, Samyukta
Suzuki, Seigo
Sawada, Toshiki
Lim, Sierin
Serizawa, Takeshi
Preparation and dynamic behavior of protein-polymer complexes formed with polymer-binding peptides
description The development of protein-polymer complexes using protein cages is garnering attention as a strategy to overcome challenges that relate to immunogenicity and protease degradation. We propose the use of thermoresponsive polymers such as poly(N-isopropylacrylamide) (PNIPAM) to form ferritin-polymer complexes through non-covalent interactions. Ferritin is observed to be released from the complexes after 1–2 days incubation at 37 °C.
author2 School of Chemical and Biomedical Engineering
author_facet School of Chemical and Biomedical Engineering
Ravishankar, Samyukta
Suzuki, Seigo
Sawada, Toshiki
Lim, Sierin
Serizawa, Takeshi
format Article
author Ravishankar, Samyukta
Suzuki, Seigo
Sawada, Toshiki
Lim, Sierin
Serizawa, Takeshi
author_sort Ravishankar, Samyukta
title Preparation and dynamic behavior of protein-polymer complexes formed with polymer-binding peptides
title_short Preparation and dynamic behavior of protein-polymer complexes formed with polymer-binding peptides
title_full Preparation and dynamic behavior of protein-polymer complexes formed with polymer-binding peptides
title_fullStr Preparation and dynamic behavior of protein-polymer complexes formed with polymer-binding peptides
title_full_unstemmed Preparation and dynamic behavior of protein-polymer complexes formed with polymer-binding peptides
title_sort preparation and dynamic behavior of protein-polymer complexes formed with polymer-binding peptides
publishDate 2021
url https://hdl.handle.net/10356/152844
_version_ 1715201488441049088

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