PLGA nanoparticles and microspheres for controlled drug delivery.

Drug delivery systems are attracting more and more funding in recent years among other hot research topics. Producers and consumers increasingly realize the importance of such drug delivery mechanisms and the benefits they bring to human beings. Typically, polymers are the best drug delivery carrier...

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Main Author: Gong, Tianxing.
Other Authors: Boey Yin Chiang, Freddy
Format: Final Year Project
Language:English
Published: 2009
Subjects:
Online Access:http://hdl.handle.net/10356/15319
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-153192023-03-04T15:38:45Z PLGA nanoparticles and microspheres for controlled drug delivery. Fabrication of PLGA microspheres via spray drying Gong, Tianxing. Boey Yin Chiang, Freddy School of Materials Science and Engineering DRNTU::Engineering::Materials::Biomaterials Drug delivery systems are attracting more and more funding in recent years among other hot research topics. Producers and consumers increasingly realize the importance of such drug delivery mechanisms and the benefits they bring to human beings. Typically, polymers are the best drug delivery carriers, as compared to metals. Their degraded products are less toxic and easy to be excreted from the body. Moreover polymers are more flexible than ceramics and provide good patient compliance. The selection of polymers is limited by biocompatibility, biodegradability and monomers’ toxicity. Few polymers are available and safe to be in drug delivery system, and the pending time in which the material suppliers are waiting for the approval of polymer safety from the national authority is decades of time. Therefore, the development of currently available biopolymers is timely and the most economic option. Poly [(lactic acid)-co-(glycolic acid)] (PLGA) is one of biopolymers being widely used for years. One advantage of PLGA is bioerosion products, oligomers or monomers, which are biocompatible with the physiological environment. Interests in developing shape of microspherical particles, as part of entire drug delivery system, are evident in our school biomaterial laboratory. Moreover, the size of those microspheres and surface conditions are of importance as well, since they affect absorption into bloodstream. In my final year project (FYP), the focus is on developing PLGA microspheres of 2μm in diameter and smooth surfaces by using the spray drying technique. PLGA has several molar compositions, and in my project, I only tried PLGA (75/25) and PLGA (53/43). The solvents used to dissolve the polymer are acetone, which is more important, and chloroform. From my research I obtained the desired results and learnt precious information from these experiments. More importantly, I managed to put together the ways to predict particle size and optimal operational parameters, which could benefit other researchers in future attempts. Bachelor of Engineering (Materials Engineering) 2009-04-27T07:47:19Z 2009-04-27T07:47:19Z 2009 2009 Final Year Project (FYP) http://hdl.handle.net/10356/15319 en Nanyang Technological University 76 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Engineering::Materials::Biomaterials
spellingShingle DRNTU::Engineering::Materials::Biomaterials
Gong, Tianxing.
PLGA nanoparticles and microspheres for controlled drug delivery.
description Drug delivery systems are attracting more and more funding in recent years among other hot research topics. Producers and consumers increasingly realize the importance of such drug delivery mechanisms and the benefits they bring to human beings. Typically, polymers are the best drug delivery carriers, as compared to metals. Their degraded products are less toxic and easy to be excreted from the body. Moreover polymers are more flexible than ceramics and provide good patient compliance. The selection of polymers is limited by biocompatibility, biodegradability and monomers’ toxicity. Few polymers are available and safe to be in drug delivery system, and the pending time in which the material suppliers are waiting for the approval of polymer safety from the national authority is decades of time. Therefore, the development of currently available biopolymers is timely and the most economic option. Poly [(lactic acid)-co-(glycolic acid)] (PLGA) is one of biopolymers being widely used for years. One advantage of PLGA is bioerosion products, oligomers or monomers, which are biocompatible with the physiological environment. Interests in developing shape of microspherical particles, as part of entire drug delivery system, are evident in our school biomaterial laboratory. Moreover, the size of those microspheres and surface conditions are of importance as well, since they affect absorption into bloodstream. In my final year project (FYP), the focus is on developing PLGA microspheres of 2μm in diameter and smooth surfaces by using the spray drying technique. PLGA has several molar compositions, and in my project, I only tried PLGA (75/25) and PLGA (53/43). The solvents used to dissolve the polymer are acetone, which is more important, and chloroform. From my research I obtained the desired results and learnt precious information from these experiments. More importantly, I managed to put together the ways to predict particle size and optimal operational parameters, which could benefit other researchers in future attempts.
author2 Boey Yin Chiang, Freddy
author_facet Boey Yin Chiang, Freddy
Gong, Tianxing.
format Final Year Project
author Gong, Tianxing.
author_sort Gong, Tianxing.
title PLGA nanoparticles and microspheres for controlled drug delivery.
title_short PLGA nanoparticles and microspheres for controlled drug delivery.
title_full PLGA nanoparticles and microspheres for controlled drug delivery.
title_fullStr PLGA nanoparticles and microspheres for controlled drug delivery.
title_full_unstemmed PLGA nanoparticles and microspheres for controlled drug delivery.
title_sort plga nanoparticles and microspheres for controlled drug delivery.
publishDate 2009
url http://hdl.handle.net/10356/15319
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