Impact of BMI and waist circumference on epigenome-wide DNA methylation and identification of epigenetic biomarkers in blood : an EWAS in multi-ethnic Asian individuals
The prevalence of obesity and its related chronic diseases have been increasing especially in Asian countries. Obesity-related genetic variants have been identified, but these explain little of the variation in BMI. Recent studies reported associations between DNA methylation and obesity, mostly in...
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sg-ntu-dr.10356-1536152023-03-05T16:43:41Z Impact of BMI and waist circumference on epigenome-wide DNA methylation and identification of epigenetic biomarkers in blood : an EWAS in multi-ethnic Asian individuals Chen, Yuqing Kassam, Irfahan Lau, Suk Hiang Kooner, Jaspal S. Wilson, Rory Peters, Annette Winkelmann, Juliane Chambers, John C. Chow, Vincent T. Khor, Chiea Chuen Van Dam, Rob M. Teo, Yik-Ying Loh, Marie Sim, Xueling Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine DNA Methylation Epigenome-Wide Association Study The prevalence of obesity and its related chronic diseases have been increasing especially in Asian countries. Obesity-related genetic variants have been identified, but these explain little of the variation in BMI. Recent studies reported associations between DNA methylation and obesity, mostly in non-Asian populations. Agency for Science, Technology and Research (A*STAR) Ministry of Health (MOH) National Medical Research Council (NMRC) National Research Foundation (NRF) Published version This research is supported by the Singapore Ministry of Health’s National Medical Research Council (NMRC/OFYIRG/038/2017-00). The iOmics study is supported by the Biomedical Research Council (grant 03/1/27/18/216), National Medical Research Council (grant 0838/2004) and National Research Foundation (through the Bio-medical Research Council, grants 05/1/21/19/425 and 11/1/21/19/678), and is partly supported by funds from the Agency for Science, Technology and Research (A∗STAR) and the National University of Singapore (NUS) [Translational Laboratory in Genetic Medicine— Integrative Omics Group (TLGM-iOX)]. The contributions from the KORA study were supported by a grant (01EA1902A: Dimension) from the German Federal Ministry of Education and Research (BMBF) within the framework of the EU Joint Programming Initiative ‘A Healthy Diet for a Healthy Life’. 2021-12-14T07:59:20Z 2021-12-14T07:59:20Z 2021 Journal Article Chen, Y., Kassam, I., Lau, S. H., Kooner, J. S., Wilson, R., Peters, A., Winkelmann, J., Chambers, J. C., Chow, V. T., Khor, C. C., Van Dam, R. M., Teo, Y., Loh, M. & Sim, X. (2021). Impact of BMI and waist circumference on epigenome-wide DNA methylation and identification of epigenetic biomarkers in blood : an EWAS in multi-ethnic Asian individuals. Clinical Epigenetics, 13(1), 195-. https://dx.doi.org/10.1186/s13148-021-01162-x 1868-7075 https://hdl.handle.net/10356/153615 10.1186/s13148-021-01162-x 34670603 2-s2.0-85117604039 1 13 195 en NMRC/OFYIRG/038/2017-00 03/1/27/18/216 0838/2004 05/1/21/19/425 11/1/21/19/678 Clinical Epigenetics © 2021 The Author(s). Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativeco mmons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. application/pdf |
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Science::Medicine DNA Methylation Epigenome-Wide Association Study |
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Science::Medicine DNA Methylation Epigenome-Wide Association Study Chen, Yuqing Kassam, Irfahan Lau, Suk Hiang Kooner, Jaspal S. Wilson, Rory Peters, Annette Winkelmann, Juliane Chambers, John C. Chow, Vincent T. Khor, Chiea Chuen Van Dam, Rob M. Teo, Yik-Ying Loh, Marie Sim, Xueling Impact of BMI and waist circumference on epigenome-wide DNA methylation and identification of epigenetic biomarkers in blood : an EWAS in multi-ethnic Asian individuals |
| description |
The prevalence of obesity and its related chronic diseases have been increasing especially in Asian countries. Obesity-related genetic variants have been identified, but these explain little of the variation in BMI. Recent studies reported associations between DNA methylation and obesity, mostly in non-Asian populations. |
| author2 |
Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet |
Lee Kong Chian School of Medicine (LKCMedicine) Chen, Yuqing Kassam, Irfahan Lau, Suk Hiang Kooner, Jaspal S. Wilson, Rory Peters, Annette Winkelmann, Juliane Chambers, John C. Chow, Vincent T. Khor, Chiea Chuen Van Dam, Rob M. Teo, Yik-Ying Loh, Marie Sim, Xueling |
| format |
Article |
| author |
Chen, Yuqing Kassam, Irfahan Lau, Suk Hiang Kooner, Jaspal S. Wilson, Rory Peters, Annette Winkelmann, Juliane Chambers, John C. Chow, Vincent T. Khor, Chiea Chuen Van Dam, Rob M. Teo, Yik-Ying Loh, Marie Sim, Xueling |
| author_sort |
Chen, Yuqing |
| title |
Impact of BMI and waist circumference on epigenome-wide DNA methylation and identification of epigenetic biomarkers in blood : an EWAS in multi-ethnic Asian individuals |
| title_short |
Impact of BMI and waist circumference on epigenome-wide DNA methylation and identification of epigenetic biomarkers in blood : an EWAS in multi-ethnic Asian individuals |
| title_full |
Impact of BMI and waist circumference on epigenome-wide DNA methylation and identification of epigenetic biomarkers in blood : an EWAS in multi-ethnic Asian individuals |
| title_fullStr |
Impact of BMI and waist circumference on epigenome-wide DNA methylation and identification of epigenetic biomarkers in blood : an EWAS in multi-ethnic Asian individuals |
| title_full_unstemmed |
Impact of BMI and waist circumference on epigenome-wide DNA methylation and identification of epigenetic biomarkers in blood : an EWAS in multi-ethnic Asian individuals |
| title_sort |
impact of bmi and waist circumference on epigenome-wide dna methylation and identification of epigenetic biomarkers in blood : an ewas in multi-ethnic asian individuals |
| publishDate |
2021 |
| url |
https://hdl.handle.net/10356/153615 |
| _version_ |
1759856665195184128 |