Impact of BMI and waist circumference on epigenome-wide DNA methylation and identification of epigenetic biomarkers in blood : an EWAS in multi-ethnic Asian individuals

• Main Authors: Chen, Yuqing, Kassam, Irfahan, Lau, Suk Hiang, Kooner, Jaspal S., Wilson, Rory, Peters, Annette, Winkelmann, Juliane, Chambers, John C., Chow, Vincent T., Khor, Chiea Chuen, Van Dam, Rob M., Teo, Yik-Ying, Loh, Marie, Sim, Xueling
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Medicine; DNA Methylation; Epigenome-Wide Association Study
• Online Access: https://hdl.handle.net/10356/153615
• Institution: Nanyang Technological University

The prevalence of obesity and its related chronic diseases have been increasing especially in Asian countries. Obesity-related genetic variants have been identified, but these explain little of the variation in BMI. Recent studies reported associations between DNA methylation and obesity, mostly in...