GDF15 mediates the metabolic effects of PPARβ/δ by activating AMPK

• Main Authors: Aguilar-Recarte, David, Barroso, Emma, Gumà, Anna, Pizarro-Delgado, Javier, Peña, Lucía, Ruart, Maria, Palomer, Xavier, Wahli, Walter, Vázquez-Carrera, Manuel
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Medicine; Growth Differentiation Factor 15; PPARβ/δ
• Online Access: https://hdl.handle.net/10356/153809
• Institution: Nanyang Technological University

Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) activates AMP-activated protein kinase (AMPK) and plays a crucial role in glucose and lipid metabolism. Here, we examine whether PPARβ/δ activation effects depend on growth differentiation factor 15 (GDF15), a stress response cytokine that reg...