Differential cytokine responses in hospitalized COVID-19 patients limit efficacy of Remdesivir

• Main Authors: Chan, Yi-Hao, Young, Barnaby Edward, Fong, Siew-Wai, Ding, Ying, Goh, Yun Shan, Chee, Rhonda Sin-Ling, Tan, Seow-Yen, Kalimuddin, Shirin, Tambyah, Paul A., Leo, Yee Sin, Ng, Lisa F. P., Lye, David C., Renia, Laurent
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; COVID-19; Remdesivir (GS-5734)
• Online Access: https://hdl.handle.net/10356/154178
• Institution: Nanyang Technological University

A significant proportion of COVID-19 patients will progress to critical illness requiring invasive mechanical ventilation. This accentuates the need for a therapy that can reduce the severity of COVID-19. Clinical trials have shown the effectiveness of remdesivir in shortening recovery time and decr...