Fatty acid oxidation is a druggable gateway regulating cellular plasticity for driving metastasis in breast cancer

• المؤلفون الرئيسيون: Loo, Ser Yue, Toh, Li Ping, Xie, William Haowei, Pathak, Elina, Tan, Wilson, Ma, Siming, Lee, May Yin, Shatishwaran, S., Yeo, Joanna Zhen Zhen, Yuan, Ju, Ho, Yin Ying, Peh, Esther Kai Lay, Muniandy, Magendran, Torta, Federico, Chan, Jack, Tan, Tira J., Sim, Yirong, Tan, Veronique, Tan, Benita, Madhukumar, Preetha, Yong, Wei Sean, Ong, Kong Wee, Wong, Chow Yin, Tan, Puay Hoon, Yap, Yoon Sim, Deng, Lih-Wen, Dent, Rebecca, Foo, Roger, Wenk, Markus R., Lee, Soo Chin, Ho, Ying Swan, Lim, Elaine Hsuen, Tam, Wai Leong
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2022
• الموضوعات: Science::Biological sciences; Epithelial-Mesenchymal Transition; Retinoic Acid
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/154360
• المؤسسة: Nanyang Technological University

Cell state transitions control the functional behavior of cancer cells. Epithelial-to-mesenchymal transition (EMT) confers cancer stem cell-like properties, enhanced tumorigenicity and drug resistance to tumor cells, while mesenchymal-epithelial transition (MET) reverses these phenotypes. Using high...