Lasing-encoded microsensor driven by interfacial cavity resonance energy transfer

Microlasers are emerging tools for biomedical applications. In particular, whispering-gallery-mode (WGM) microlasers are promising candidates for sensing at the biointerface owing to their high quality-factor and potential in molecular assays, and intracellular and extracellular detection. However,...

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Main Authors: Yuan, Zhiyi, Wang, Ziyihui, Guan, Peng, Wu, Xiaoqin, Chen, Yu-Cheng
Other Authors: School of Electrical and Electronic Engineering
Format: Article
Language:English
Published: 2022
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Online Access:https://hdl.handle.net/10356/154734
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1547342022-01-14T06:44:59Z Lasing-encoded microsensor driven by interfacial cavity resonance energy transfer Yuan, Zhiyi Wang, Ziyihui Guan, Peng Wu, Xiaoqin Chen, Yu-Cheng School of Electrical and Electronic Engineering School of Chemical and Biomedical Engineering Engineering::Electrical and electronic engineering Energy Transfer Interface Microlasers are emerging tools for biomedical applications. In particular, whispering-gallery-mode (WGM) microlasers are promising candidates for sensing at the biointerface owing to their high quality-factor and potential in molecular assays, and intracellular and extracellular detection. However, lasing particles with sensing functionality remain challenging since the overlap between the WGM optical mode and external gain medium is much lower compared to internal gain inside the cavity. To overcome this problem, the concept of Förster resonant energy transfer (FRET) is exploited on WGM droplet microlaser by separating donor and acceptor molecules at the cavity–surface interface. It is first discovered that the interfacial FRET laser not only originates from conventional FRET but utilizes coherent radiative energy transfer (CRET) to excite acceptor molecules by inducing light-harvesting effect near the cavity interface. Simulations and experiments have revealed that the absorption spectrum of individual analyte plays a crucial role in interfacial FRET laser. Distinct lasing spectra can therefore distinguish molecules of different absorption properties upon binding. Finally, detection of small fluorescent molecules and photosynthetic protein is performed. The results presented here not only demonstrate the wide-ranging potential of microlaser external cavity implementation in molecular sensing applications, but also provide comprehensive insights into cavity energy transfer in laser physics. Nanyang Technological University The authors would like to thank Prof. Yu-Chieh Cheng at the National Taipei University of Science and Technology for instruction on liquid crystal laser fabrication. The authors would like to thank the lab support from Centre of Bio-Devices and Signal Analysis and Internal Grant NAP SUG – M4082308.040 from NTU. 2022-01-05T07:58:10Z 2022-01-05T07:58:10Z 2020 Journal Article Yuan, Z., Wang, Z., Guan, P., Wu, X. & Chen, Y. (2020). Lasing-encoded microsensor driven by interfacial cavity resonance energy transfer. Advanced Optical Materials, 8(7), 1901596-. https://dx.doi.org/10.1002/adom.201901596 2195-1071 https://hdl.handle.net/10356/154734 10.1002/adom.201901596 2-s2.0-85078663931 7 8 1901596 en M4082308.040 Advanced Optical Materials © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. All rights reserved.
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Engineering::Electrical and electronic engineering
Energy Transfer
Interface
spellingShingle Engineering::Electrical and electronic engineering
Energy Transfer
Interface
Yuan, Zhiyi
Wang, Ziyihui
Guan, Peng
Wu, Xiaoqin
Chen, Yu-Cheng
Lasing-encoded microsensor driven by interfacial cavity resonance energy transfer
description Microlasers are emerging tools for biomedical applications. In particular, whispering-gallery-mode (WGM) microlasers are promising candidates for sensing at the biointerface owing to their high quality-factor and potential in molecular assays, and intracellular and extracellular detection. However, lasing particles with sensing functionality remain challenging since the overlap between the WGM optical mode and external gain medium is much lower compared to internal gain inside the cavity. To overcome this problem, the concept of Förster resonant energy transfer (FRET) is exploited on WGM droplet microlaser by separating donor and acceptor molecules at the cavity–surface interface. It is first discovered that the interfacial FRET laser not only originates from conventional FRET but utilizes coherent radiative energy transfer (CRET) to excite acceptor molecules by inducing light-harvesting effect near the cavity interface. Simulations and experiments have revealed that the absorption spectrum of individual analyte plays a crucial role in interfacial FRET laser. Distinct lasing spectra can therefore distinguish molecules of different absorption properties upon binding. Finally, detection of small fluorescent molecules and photosynthetic protein is performed. The results presented here not only demonstrate the wide-ranging potential of microlaser external cavity implementation in molecular sensing applications, but also provide comprehensive insights into cavity energy transfer in laser physics.
author2 School of Electrical and Electronic Engineering
author_facet School of Electrical and Electronic Engineering
Yuan, Zhiyi
Wang, Ziyihui
Guan, Peng
Wu, Xiaoqin
Chen, Yu-Cheng
format Article
author Yuan, Zhiyi
Wang, Ziyihui
Guan, Peng
Wu, Xiaoqin
Chen, Yu-Cheng
author_sort Yuan, Zhiyi
title Lasing-encoded microsensor driven by interfacial cavity resonance energy transfer
title_short Lasing-encoded microsensor driven by interfacial cavity resonance energy transfer
title_full Lasing-encoded microsensor driven by interfacial cavity resonance energy transfer
title_fullStr Lasing-encoded microsensor driven by interfacial cavity resonance energy transfer
title_full_unstemmed Lasing-encoded microsensor driven by interfacial cavity resonance energy transfer
title_sort lasing-encoded microsensor driven by interfacial cavity resonance energy transfer
publishDate 2022
url https://hdl.handle.net/10356/154734
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