Synthesis of α-alkynylnitrones via hydromagnesiation of 1,3-enynes with magnesium hydride

Synthesis of α-alkynylnitrones via hydromagnesiation of 1,3-enynes with magnesium hydride

A protocol for the synthesis of α-alkynylnitrones from 1,3-enynes has been developed. The process is triggered by hydromagnesiation of 1,3-enynes with magnesium hydride (MgH2), which is prepared in situ through solvothermal treatment of magnesium iodide (MgI2) with sodium hydride (NaH) in tetrahydro...

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Bibliographic Details
Main Authors: Li, Yihang, Ng, Jia Sheng, Wang, Bin, Chiba, Shunsuke
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2022
Subjects:
Science::Chemistry
Functionalization
Redox Reactions
Online Access:https://hdl.handle.net/10356/154828
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Institution: Nanyang Technological University
Language: English
Description
Summary:A protocol for the synthesis of α-alkynylnitrones from 1,3-enynes has been developed. The process is triggered by hydromagnesiation of 1,3-enynes with magnesium hydride (MgH2), which is prepared in situ through solvothermal treatment of magnesium iodide (MgI2) with sodium hydride (NaH) in tetrahydrofuran. Downstream functionalization of the resulting propargylmagnesium intermediates with organo nitro compounds affords α-alkynylnitrones, which could be used as versatile precursors for the construction of various nitrogen-containing compounds.

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