Synthesis of α-alkynylnitrones via hydromagnesiation of 1,3-enynes with magnesium hydride

• Main Authors: Li, Yihang, Ng, Jia Sheng, Wang, Bin, Chiba, Shunsuke
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Chemistry; Functionalization; Redox Reactions
• Online Access: https://hdl.handle.net/10356/154828
• Institution: Nanyang Technological University

A protocol for the synthesis of α-alkynylnitrones from 1,3-enynes has been developed. The process is triggered by hydromagnesiation of 1,3-enynes with magnesium hydride (MgH2), which is prepared in situ through solvothermal treatment of magnesium iodide (MgI2) with sodium hydride (NaH) in tetrahydro...