Linking of alcohols with vinyl azides
A protocol to link alcohols with vinyl azides has been established through fluoro- or bromo-alkoxylation of vinyl azides to provide α-alkoxy-β-haloalkyl azides. A series of primary and secondary alcohols including natural products and their derivatives such as sugars and steroids were successfully a...
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sg-ntu-dr.10356-1548662023-02-28T19:59:16Z Linking of alcohols with vinyl azides Wang, Yi-Feng Hu, Ming Hayashi, Hirohito Xing, Bengang Chiba, Shunsuke School of Physical and Mathematical Sciences Science::Chemistry Azides Hydrocarbons A protocol to link alcohols with vinyl azides has been established through fluoro- or bromo-alkoxylation of vinyl azides to provide α-alkoxy-β-haloalkyl azides. A series of primary and secondary alcohols including natural products and their derivatives such as sugars and steroids were successfully anchored with vinyl azides. The as-prepared cyanine dye linked testosterones were capable of rapid cell membrane imaging in real time. Ministry of Education (MOE) Nanyang Technological University Accepted version This work was supported by funding from Nanyang Technological University and the Singapore Ministry of Education (Academic Research Fund Tier 2: MOE2013-T2- 1-060 for S.C.). 2022-01-14T07:29:46Z 2022-01-14T07:29:46Z 2016 Journal Article Wang, Y., Hu, M., Hayashi, H., Xing, B. & Chiba, S. (2016). Linking of alcohols with vinyl azides. Organic Letters, 18(5), 992-995. https://dx.doi.org/10.1021/acs.orglett.6b00116 1523-7060 https://hdl.handle.net/10356/154866 10.1021/acs.orglett.6b00116 26914180 2-s2.0-84960157767 5 18 992 995 en MOE2013-T2-1-060 Organic Letters This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.orglett.6b00116. application/pdf |
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Science::Chemistry Azides Hydrocarbons |
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Science::Chemistry Azides Hydrocarbons Wang, Yi-Feng Hu, Ming Hayashi, Hirohito Xing, Bengang Chiba, Shunsuke Linking of alcohols with vinyl azides |
| description |
A protocol to link alcohols with vinyl azides has been established through fluoro- or bromo-alkoxylation of vinyl azides to provide α-alkoxy-β-haloalkyl azides. A series of primary and secondary alcohols including natural products and their derivatives such as sugars and steroids were successfully anchored with vinyl azides. The as-prepared cyanine dye linked testosterones were capable of rapid cell membrane imaging in real time. |
| author2 |
School of Physical and Mathematical Sciences |
| author_facet |
School of Physical and Mathematical Sciences Wang, Yi-Feng Hu, Ming Hayashi, Hirohito Xing, Bengang Chiba, Shunsuke |
| format |
Article |
| author |
Wang, Yi-Feng Hu, Ming Hayashi, Hirohito Xing, Bengang Chiba, Shunsuke |
| author_sort |
Wang, Yi-Feng |
| title |
Linking of alcohols with vinyl azides |
| title_short |
Linking of alcohols with vinyl azides |
| title_full |
Linking of alcohols with vinyl azides |
| title_fullStr |
Linking of alcohols with vinyl azides |
| title_full_unstemmed |
Linking of alcohols with vinyl azides |
| title_sort |
linking of alcohols with vinyl azides |
| publishDate |
2022 |
| url |
https://hdl.handle.net/10356/154866 |
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1759855749598543872 |