Resident macrophages restrain pathological adipose tissue remodeling and protect vascular integrity in obese mice

• Main Authors: Chen, Qi, Lai, Si Min, Xu, Shaohai, Tan, Yingrou, Leong, Keith, Liu, Dehua, Tan, Jia Chi, Naik, Roshan Ratnakar, Barron, Anna M., Adav, Sunil S., Chen, Jinmiao, Chong, Shu Zhen, Ng, Lai Guan, Ruedl, Christiane
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences; Adipocyte Hypertrophy; Fibrosis
• Online Access: https://hdl.handle.net/10356/155110
• Institution: Nanyang Technological University

Tissue-resident macrophages in white adipose tissue (WAT) dynamically adapt to the metabolic changes of their microenvironment that are often induced by excess energy intake. Currently, the exact contribution of these macrophages in obesity-driven WAT remodeling remains controversial. Here, using a...