Chemo-selective cross reaction of two enals via carbene-catalyzed dual activation

• Main Authors: Peng, Xiaolin, Xu, Jun, Li, Tingting, Chi, Robin Yonggui, Jin, Zhichao
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Chemistry; Catalysts; Enantioselectivity
• Online Access: https://hdl.handle.net/10356/155113
• Institution: Nanyang Technological University

A dual catalytic chemo-selective cross-coupling reaction of two enals is developed. One enal (without α-substitution) is activated by an NHC catalyst to form an acylazolium enolate intermediate that undergoes Michael-type addition to another enal molecule bearing an alkynyl substituent. Mechanistic...