NIR-light-intensified hypoxic microenvironment for cascaded supra-prodrug activation and synergistic chemo/photodynamic cancer therapy
Despite that photodynamic therapy (PDT) has promising clinical prospect, its therapeutic efficacy is still restricted by the hypoxic tumor microenvironment (TME). Therefore, how to suitably employ the tumor hypoxia is vital for optimizing PDT. Herein, we developed a hypoxia-activated prodrug for com...
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sg-ntu-dr.10356-1559372023-02-28T19:26:46Z NIR-light-intensified hypoxic microenvironment for cascaded supra-prodrug activation and synergistic chemo/photodynamic cancer therapy Chen, Hongzhong Sun, Tao Zeng, Weiwei Zeng, Xiaowei Mei, Lin Jiang, Chen Zhao, Yanli School of Physical and Mathematical Sciences Science::Chemistry Hypoxia Cancer Despite that photodynamic therapy (PDT) has promising clinical prospect, its therapeutic efficacy is still restricted by the hypoxic tumor microenvironment (TME). Therefore, how to suitably employ the tumor hypoxia is vital for optimizing PDT. Herein, we developed a hypoxia-activated prodrug for combination therapy with PDT. A hypoxia-responsive camptothecin (CPT)-based prodrug and a near-infrared (NIR) BODIPY photosensitizer were co-loaded within a -cyclodextrin-based polymer through supramolecular host-guest recognition to obtain nanoparticles named as CPT-BODIPY-PNs. After being internalized by tumor, the oxygen in the tumor tissues was rapidly consumed by the photosensitizer moiety to generate reactive oxygen species under NIR irradiation. The prodrug was efficiently activated under this intensified hypoxic condition to release chemotherapeutic CPT drug. This system makes the best use of hypoxia TME to achieve effectively combined PDT and chemotherapy, offering an approach for cancer treatment. Agency for Science, Technology and Research (A*STAR) National Research Foundation (NRF) Submitted/Accepted version This work was financially supported by the National Natural Science Foundation of China (32101065, 31922042 and 81771966), the Fundamental Research Funds for the Central Universities (2020-RC320-002 and 2019PT320028), the Singapore Agency for Science, Technology and Research (A*STAR) AME IRG grant (A20E5c0081), and the Singapore National Research Foundation Investigatorship (NRFNRFI2018-03). 2022-03-25T05:56:52Z 2022-03-25T05:56:52Z 2022 Journal Article Chen, H., Sun, T., Zeng, W., Zeng, X., Mei, L., Jiang, C. & Zhao, Y. (2022). NIR-light-intensified hypoxic microenvironment for cascaded supra-prodrug activation and synergistic chemo/photodynamic cancer therapy. ACS Materials Letters, 4(1), 111-119. https://dx.doi.org/10.1021/acsmaterialslett.1c00677 2639-4979 https://hdl.handle.net/10356/155937 10.1021/acsmaterialslett.1c00677 1 4 111 119 en A20E5c0081 NRFNRFI2018-03 ACS Materials Letters This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Materials Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acsmaterialslett.1c00677. application/pdf |
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Science::Chemistry Hypoxia Cancer Chen, Hongzhong Sun, Tao Zeng, Weiwei Zeng, Xiaowei Mei, Lin Jiang, Chen Zhao, Yanli NIR-light-intensified hypoxic microenvironment for cascaded supra-prodrug activation and synergistic chemo/photodynamic cancer therapy |
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Despite that photodynamic therapy (PDT) has promising clinical prospect, its therapeutic efficacy is still restricted by the hypoxic tumor microenvironment (TME). Therefore, how to suitably employ the tumor hypoxia is vital for optimizing PDT. Herein, we developed a hypoxia-activated prodrug for combination therapy with PDT. A hypoxia-responsive camptothecin (CPT)-based prodrug and a near-infrared (NIR) BODIPY photosensitizer were co-loaded within a -cyclodextrin-based polymer through supramolecular host-guest recognition to obtain nanoparticles named as CPT-BODIPY-PNs. After being internalized by tumor, the oxygen in the tumor tissues was rapidly consumed by the photosensitizer moiety to generate reactive oxygen species under NIR irradiation. The prodrug was efficiently activated under this intensified hypoxic condition to release chemotherapeutic CPT drug. This system makes the best use of hypoxia TME to achieve effectively combined PDT and chemotherapy, offering an approach for cancer treatment. |
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School of Physical and Mathematical Sciences |
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School of Physical and Mathematical Sciences Chen, Hongzhong Sun, Tao Zeng, Weiwei Zeng, Xiaowei Mei, Lin Jiang, Chen Zhao, Yanli |
format |
Article |
author |
Chen, Hongzhong Sun, Tao Zeng, Weiwei Zeng, Xiaowei Mei, Lin Jiang, Chen Zhao, Yanli |
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Chen, Hongzhong |
title |
NIR-light-intensified hypoxic microenvironment for cascaded supra-prodrug activation and synergistic chemo/photodynamic cancer therapy |
title_short |
NIR-light-intensified hypoxic microenvironment for cascaded supra-prodrug activation and synergistic chemo/photodynamic cancer therapy |
title_full |
NIR-light-intensified hypoxic microenvironment for cascaded supra-prodrug activation and synergistic chemo/photodynamic cancer therapy |
title_fullStr |
NIR-light-intensified hypoxic microenvironment for cascaded supra-prodrug activation and synergistic chemo/photodynamic cancer therapy |
title_full_unstemmed |
NIR-light-intensified hypoxic microenvironment for cascaded supra-prodrug activation and synergistic chemo/photodynamic cancer therapy |
title_sort |
nir-light-intensified hypoxic microenvironment for cascaded supra-prodrug activation and synergistic chemo/photodynamic cancer therapy |
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2022 |
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https://hdl.handle.net/10356/155937 |
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1759858050479423488 |