Single cell metabolite detection using inertial microfluidics-assisted ion mobility mass spectrometry

• Main Authors: Zhang, Leicheng, Xu, Tengfei, Zhang, Jingtao, Wong, Stephen Choong Chee, Ritchie, Mark, Hou, Han Wei, Wang, Yulan
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Engineering::Mechanical engineering; Cell Culture; Ion Mobility Spectrometers
• Online Access: https://hdl.handle.net/10356/159342
• Institution: Nanyang Technological University

Single-cell metabolite measurement remains highly challenging due to difficulties related to single cell isolation, metabolite detection, and identification of low levels of metabolites. Here, as a first step of the technological development, we propose a novel strategy integrating spiral inertial m...