Aging-induced isoDGR-modified fibronectin activates monocytic and endothelial cells to promote atherosclerosis

• Main Authors: Park, Jung Eun, JebaMercy, Gnanasekaran, Pazhanchamy, Kalailingam, Guo, Xue, Ngan, SoFong Cam, Liou, Ken Cheng Kang, Soe, Lynn EinSi, Ng, Ser Sue, Meng, Wei, Lim, Su Chi, Leow, Melvin Khee-Shing, Richards, A. Mark, Pennington, Daniel J., de Kleijn, Dominique P. V., Sorokin, Vitaly, Ho, Hee Hwa, McCarthy, Neil E., Sze, Siu Kwan
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences; Science::Medicine; Atherosclerosis; Vascular Inflammation
• Online Access: https://hdl.handle.net/10356/159531
• Institution: Nanyang Technological University

Background and aims: Aging is the primary risk factor for cardiovascular disease (CVD), but the mechanisms underlying age-linked atherosclerosis remain unclear. We previously observed that long-lived vascular matrix proteins can acquire 'gain-of-function' isoDGR motifs that might play a ro...