Catalytic asymmetric diarylphosphine addition to α-diazoesters for the synthesis of P-stereogenic phosphinates via P*-N bond formation

• Main Authors: Balázs, László B., Huang, Yinhua, Khalikuzzaman, Jasmina B., Li, Yongxin, Pullarkat, Sumod A., Leung, Pak-Hing
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Chemistry; Alpha Diazoester Derivative; Diarylphosphine
• Online Access: https://hdl.handle.net/10356/159533
• Institution: Nanyang Technological University

The asymmetric catalytic P-H addition of racemic secondary phosphines to electrophilic α-diazoesters via P*-N bond formation is disclosed for the first time. Interaction between the diazoester and the palladium catalyst resulted in the unusually enhanced electrophilic ability of the terminal nitroge...