Photoinitiated stereoselective direct C(sp²)–H perfluoroalkylation and difluoroacetylation of enamides
A photoinitiated perfluoroalkylative coupling of enamides with perfluoroalkyl iodides and a visible-light-induced difluoroacetylation of enamides with ethyl bromodifluoroacetate have been developed, respectively. These transformations allow the efficacious and straightforward incorporation of biolog...
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sg-ntu-dr.10356-1599972022-07-07T05:56:22Z Photoinitiated stereoselective direct C(sp²)–H perfluoroalkylation and difluoroacetylation of enamides Zhao, Kai Guo, Jing-Yu Guan, Ting Wang, Ying-Xue Tao, Ji-Yu Zhang, Yu Zhang, Qing-Hong Ni, Kun Loh, Teck-Peng School of Physical and Mathematical Sciences Science::Chemistry Photoredox Catalysis Unactivated Alkenes A photoinitiated perfluoroalkylative coupling of enamides with perfluoroalkyl iodides and a visible-light-induced difluoroacetylation of enamides with ethyl bromodifluoroacetate have been developed, respectively. These transformations allow the efficacious and straightforward incorporation of biologically and physiologically privileged fluoro-containing moieties into synthetically eminent enamide scaffolds with excellent regio- and stereoselectivities under mild and environmentally friendly conditions. We gratefully acknowledge the financial support from the National Natural Science Foundation of China (21801129), the Natural Science Research Projects in Jiangsu Higher Education Institutions (18KJB150018), the National Students’ Platform for Innovation and Entrepreneurship Training Program (201910291012Z), Nanjing Tech University (Start-up Grant No. 39837137, 39837101 and 3827401739) and Soochow University (KJS1945). 2022-07-07T05:56:22Z 2022-07-07T05:56:22Z 2021 Journal Article Zhao, K., Guo, J., Guan, T., Wang, Y., Tao, J., Zhang, Y., Zhang, Q., Ni, K. & Loh, T. (2021). Photoinitiated stereoselective direct C(sp²)–H perfluoroalkylation and difluoroacetylation of enamides. Organic Chemistry Frontiers, 8(15), 4086-4094. https://dx.doi.org/10.1039/D1QO00605C 2052-4129 https://hdl.handle.net/10356/159997 10.1039/D1QO00605C 15 8 4086 4094 en Organic Chemistry Frontiers © 2021 the Partner Organisations. All rights reserved. |
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Science::Chemistry Photoredox Catalysis Unactivated Alkenes Zhao, Kai Guo, Jing-Yu Guan, Ting Wang, Ying-Xue Tao, Ji-Yu Zhang, Yu Zhang, Qing-Hong Ni, Kun Loh, Teck-Peng Photoinitiated stereoselective direct C(sp²)–H perfluoroalkylation and difluoroacetylation of enamides |
| description |
A photoinitiated perfluoroalkylative coupling of enamides with perfluoroalkyl iodides and a visible-light-induced difluoroacetylation of enamides with ethyl bromodifluoroacetate have been developed, respectively. These transformations allow the efficacious and straightforward incorporation of biologically and physiologically privileged fluoro-containing moieties into synthetically eminent enamide scaffolds with excellent regio- and stereoselectivities under mild and environmentally friendly conditions. |
| author2 |
School of Physical and Mathematical Sciences |
| author_facet |
School of Physical and Mathematical Sciences Zhao, Kai Guo, Jing-Yu Guan, Ting Wang, Ying-Xue Tao, Ji-Yu Zhang, Yu Zhang, Qing-Hong Ni, Kun Loh, Teck-Peng |
| format |
Article |
| author |
Zhao, Kai Guo, Jing-Yu Guan, Ting Wang, Ying-Xue Tao, Ji-Yu Zhang, Yu Zhang, Qing-Hong Ni, Kun Loh, Teck-Peng |
| author_sort |
Zhao, Kai |
| title |
Photoinitiated stereoselective direct C(sp²)–H perfluoroalkylation and difluoroacetylation of enamides |
| title_short |
Photoinitiated stereoselective direct C(sp²)–H perfluoroalkylation and difluoroacetylation of enamides |
| title_full |
Photoinitiated stereoselective direct C(sp²)–H perfluoroalkylation and difluoroacetylation of enamides |
| title_fullStr |
Photoinitiated stereoselective direct C(sp²)–H perfluoroalkylation and difluoroacetylation of enamides |
| title_full_unstemmed |
Photoinitiated stereoselective direct C(sp²)–H perfluoroalkylation and difluoroacetylation of enamides |
| title_sort |
photoinitiated stereoselective direct c(sp²)–h perfluoroalkylation and difluoroacetylation of enamides |
| publishDate |
2022 |
| url |
https://hdl.handle.net/10356/159997 |
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1738844789007187968 |