Recent advances in investigating functional dynamics of chromatin

• Main Authors: Shi, Xiangyan, Zhai, Ziwei, Chen, Yinglu, Li, Jindi, Nordenskiöld, Lars
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences; Nuclear Magnetic Resonance; Molecular Dynamics Simulations
• Online Access: https://hdl.handle.net/10356/160255
• Institution: Nanyang Technological University

Dynamics spanning the picosecond-minute time domain and the atomic-subcellular spatial window have been observed for chromatin in vitro and in vivo. The condensed organization of chromatin in eukaryotic cells prevents regulatory factors from accessing genomic DNA, which requires dynamic stabilizatio...