Water-tolerant ortho-acylation of phenols
A metal-free, water-tolerant, and one-pot process for ortho-acylation of phenols promoted by the iodine source/hydrogen peroxide system has been developed. This transformation undergoes ether formation, iodocyclization, C-C bond cleavage, and oxidative hydrolysis in a one-step manner, which is suppo...
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sg-ntu-dr.10356-1603542022-07-19T08:57:26Z Water-tolerant ortho-acylation of phenols Tian, Jie-Sheng He, Yu Gao, Zhi-Yuan Liu, Xu Dong, Shuang-Feng Wu, Peng Loh, Teck-Peng School of Physical and Mathematical Sciences Science::Chemistry Iodine Amination A metal-free, water-tolerant, and one-pot process for ortho-acylation of phenols promoted by the iodine source/hydrogen peroxide system has been developed. This transformation undergoes ether formation, iodocyclization, C-C bond cleavage, and oxidative hydrolysis in a one-step manner, which is supported by control experiments. Ministry of Education (MOE) Nanyang Technological University The authors gratefully acknowledge Northwestern Polytechnical University, the Fundamental Research Funds for the Central Universities (D5000210701), Tier 1 Grant M4012045.110 (RG12/18-S) from the Ministry of Education of Singapore, Nanjing Tech University, and Nanyang Technological University for the generous financial support. 2022-07-19T08:57:25Z 2022-07-19T08:57:25Z 2021 Journal Article Tian, J., He, Y., Gao, Z., Liu, X., Dong, S., Wu, P. & Loh, T. (2021). Water-tolerant ortho-acylation of phenols. Organic Letters, 23(16), 6594-6598. https://dx.doi.org/10.1021/acs.orglett.1c02583 1523-7060 https://hdl.handle.net/10356/160354 10.1021/acs.orglett.1c02583 34378942 2-s2.0-85113928542 16 23 6594 6598 en M4012045.110 (RG12/18-S) Organic Letters © 2021 American Chemical Society. All rights reserved. |
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Science::Chemistry Iodine Amination |
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Science::Chemistry Iodine Amination Tian, Jie-Sheng He, Yu Gao, Zhi-Yuan Liu, Xu Dong, Shuang-Feng Wu, Peng Loh, Teck-Peng Water-tolerant ortho-acylation of phenols |
| description |
A metal-free, water-tolerant, and one-pot process for ortho-acylation of phenols promoted by the iodine source/hydrogen peroxide system has been developed. This transformation undergoes ether formation, iodocyclization, C-C bond cleavage, and oxidative hydrolysis in a one-step manner, which is supported by control experiments. |
| author2 |
School of Physical and Mathematical Sciences |
| author_facet |
School of Physical and Mathematical Sciences Tian, Jie-Sheng He, Yu Gao, Zhi-Yuan Liu, Xu Dong, Shuang-Feng Wu, Peng Loh, Teck-Peng |
| format |
Article |
| author |
Tian, Jie-Sheng He, Yu Gao, Zhi-Yuan Liu, Xu Dong, Shuang-Feng Wu, Peng Loh, Teck-Peng |
| author_sort |
Tian, Jie-Sheng |
| title |
Water-tolerant ortho-acylation of phenols |
| title_short |
Water-tolerant ortho-acylation of phenols |
| title_full |
Water-tolerant ortho-acylation of phenols |
| title_fullStr |
Water-tolerant ortho-acylation of phenols |
| title_full_unstemmed |
Water-tolerant ortho-acylation of phenols |
| title_sort |
water-tolerant ortho-acylation of phenols |
| publishDate |
2022 |
| url |
https://hdl.handle.net/10356/160354 |
| _version_ |
1739837367962828800 |