Water-tolerant ortho-acylation of phenols

• Main Authors: Tian, Jie-Sheng, He, Yu, Gao, Zhi-Yuan, Liu, Xu, Dong, Shuang-Feng, Wu, Peng, Loh, Teck-Peng
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Chemistry; Iodine; Amination
• Online Access: https://hdl.handle.net/10356/160354
• Institution: Nanyang Technological University

A metal-free, water-tolerant, and one-pot process for ortho-acylation of phenols promoted by the iodine source/hydrogen peroxide system has been developed. This transformation undergoes ether formation, iodocyclization, C-C bond cleavage, and oxidative hydrolysis in a one-step manner, which is suppo...