Liquid-liquid phase separation of short histidine- and tyrosine-rich peptides: sequence specificity and molecular topology

• Main Authors: Lim, Jessica, Kumar, Akshita, Low, Kimberly Jia Yi, Verma, Chandra Shekhar, Mu, Yuguang, Miserez, Ali, Pervushin, Konstantin
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Engineering::Chemical engineering; Aromatic Residues; Proteins
• Online Access: https://hdl.handle.net/10356/160365
• Institution: Nanyang Technological University

The increasing realization of the prevalence of liquid-liquid phase separation (LLPS) across multiple length scales of biological constructs, from intracellular membraneless organelles to extracellular load-bearing tissues, has raised intriguing questions about intermolecular interactions regulating...