Impaired neurogenesis in the hippocampus of an adult VPS35 mutant mouse model of Parkinson's disease through interaction with APP

• Main Authors: Jiang, Mei, Tu, Hai-Tao, Zhang, Ke, Zhang, Wei, Yu, Wei-Ping, Xu, Jie, Tan, Eng-King, Guo, Kai-Hua, Zeng, Li
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Adult Neurogenesis; Migration
• Online Access: https://hdl.handle.net/10356/160635
• Institution: Nanyang Technological University

Vacuolar protein sorting protein 35 (VPS35) is a core component of the retromer complex involved in regulating protein trafficking and retrieval. Recently, a missense mutation, Asp620Asn (D620N), in VPS35 (PARK17) has been identified as a pathogenic mutation for late-onset autosomal dominant Parkins...