Asthma prescribing according to Arg16Gly beta-2 genotype: a randomised trial in adolescents

Asthma prescribing according to Arg16Gly beta-2 genotype: a randomised trial in adolescents

The A allele of rs1042713 (Arg16 amino acid) in the β2-adrenoreceptor is associated with poor response to long-acting β2-agonist (LABA) in young people with asthma. Our aim was to assess whether the prescribing of second-line controller with LABA or a leukotriene receptor antagonist according to Arg...

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Bibliographic Details
Main Authors: Ruffles, Tom, Jones, Christina J., Palmer, Colin, Turner, Steve, Grigg, Jonathan, Tavendale, Roger, Hogarth, Fiona, Rauchhaus, Petra, Pilvinyte, Kristina, Hannah, Romanie, Smith, Helen Elizabeth, Littleford, Roberta, Lipworth, Brian, Mukhopadhyay, Somnath
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2022
Subjects:
Science::Medicine
Quality-of-Life
Bronchoprotective Subsensitivity
Online Access:https://hdl.handle.net/10356/160848
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Institution: Nanyang Technological University
Language: English
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Summary:The A allele of rs1042713 (Arg16 amino acid) in the β2-adrenoreceptor is associated with poor response to long-acting β2-agonist (LABA) in young people with asthma. Our aim was to assess whether the prescribing of second-line controller with LABA or a leukotriene receptor antagonist according to Arg16Gly genotype would result in improvements in Pediatric Asthma-Related Quality of Life Questionnaire (PAQLQ).

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