Asthma prescribing according to Arg16Gly beta-2 genotype: a randomised trial in adolescents

• Main Authors: Ruffles, Tom, Jones, Christina J., Palmer, Colin, Turner, Steve, Grigg, Jonathan, Tavendale, Roger, Hogarth, Fiona, Rauchhaus, Petra, Pilvinyte, Kristina, Hannah, Romanie, Smith, Helen Elizabeth, Littleford, Roberta, Lipworth, Brian, Mukhopadhyay, Somnath
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Quality-of-Life; Bronchoprotective Subsensitivity
• Online Access: https://hdl.handle.net/10356/160848
• Institution: Nanyang Technological University

The A allele of rs1042713 (Arg16 amino acid) in the β2-adrenoreceptor is associated with poor response to long-acting β2-agonist (LABA) in young people with asthma. Our aim was to assess whether the prescribing of second-line controller with LABA or a leukotriene receptor antagonist according to Arg16Gly genotype would result in improvements in Pediatric Asthma-Related Quality of Life Questionnaire (PAQLQ).