Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold

Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold

Alphaviruses such as Ross River virus (RRV), chikungunya virus (CHIKV), Sindbis virus (SINV), and Venezuelan equine encephalitis virus (VEEV) are mosquito-borne pathogens that can cause arthritis or encephalitis diseases. Nonstructural protein 4 (nsP4) of alphaviruses possesses RNA-dependent RNA pol...

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Bibliographic Details
Main Authors: Tan, Yaw Bia, Lello, Laura Sandra, Liu, Xin, Law, Yee-Song, Kang, Congbao, Lescar, Julien, Zheng, Jie, Merits, Andres, Luo, Dahai
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2022
Subjects:
Science::Medicine
Science::Biological sciences
Viral Protein
Virus RNA
Online Access:https://hdl.handle.net/10356/161300
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/161300

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